Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Perspectives on hand transplantation.

W P Andrew Lee¹, Vu T Nguyen

¹Division of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. zimmerjm@upmc.edu

Clinics in Plastic Surgery

|September 6, 2005

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Enhancing Aesthetic Breast Surgery Training: A 10-Year Comparison of Outcomes Between Resident- and Attending-Led Cosmetic Breast Procedures at a Single Institution.

Aesthetic plastic surgery·2026

Same author

Absorbable antibiotic bead prophylaxis for implant-based breast reconstruction.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2025

Same author

The structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3β inhibition.

RSC medicinal chemistry·2025

Same author

RiSKs in Computational Modeling of Isoform-Selective RSK Inhibitors.

Journal of chemical information and modeling·2025

Same author

The Impact of Women-Led Academic Collaborations in Plastic Surgery.

Annals of plastic surgery·2025

Same author

A 10-Year Analysis of Resident Aesthetic Surgery Clinic: Abdominoplasty Performed by Residents Is Safe and Leads to Comparable Outcomes to Attending Surgeons.

Annals of plastic surgery·2025

Same journal

Lower-Extremity Reconstruction: Principles, Progress, and Perspectives.

Clinics in plastic surgery·2026

Same journal

Pediatric.

Clinics in plastic surgery·2026

Same journal

Lower Extremity Reconstruction in Acute Burns.

Clinics in plastic surgery·2026

Same journal

Chronic Lower Extremity Wounds: Updates on Lower Extremity Reconstruction in Clinics in Plastic Surgery.

Clinics in plastic surgery·2026

Same journal

Updates in Lower Extremity Reconstruction: Post Sarcoma.

Clinics in plastic surgery·2026

Same journal

Fillet Flaps for Lower Extremity Salvage.

Clinics in plastic surgery·2026

See all related articles

Early hand transplantation shows benefits but faces challenges. Immunosuppression is safe, but functional gains are limited, and long-term risks require further study to improve the risk-benefit balance for wider use.

Area of Science:

Surgical innovation
Transplant immunology
Reconstructive surgery

Background:

Hand transplantation offers potential benefits for patients with severe hand loss.
Early clinical experiences provide valuable insights into outcomes and challenges.

Purpose of the Study:

To evaluate the early outcomes of hand transplantation.
To assess the safety and efficacy of immunosuppression protocols.
To identify factors influencing functional recovery and long-term success.

Main Methods:

Review of early clinical cases of hand transplantation.
Analysis of adverse events related to immunosuppressive therapy.
Assessment of functional outcomes and patient-reported benefits.

Related Experiment Videos

Main Results:

No life-threatening adverse effects from immunosuppression were observed.
Additional medications were sometimes needed, with unknown long-term effects.
Limited functional recovery was achieved in early cases.
The impact of chronic rejection remains to be determined.

Conclusions:

Hand transplantation provides significant psychosocial benefits to patients and families.
Widespread adoption hinges on improving the risk-benefit ratio.
Further research is crucial to optimize immunosuppression and enhance functional outcomes.