Related Experiment Video
Updated: Aug 8, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
[Pharmacological aspects of a novel antiplatelet drug, E5510]
1Department of Internal Medicine, School of Medicine, Keio University.
Abstract:
E5510 is an antiplatelet agent, recently synthesized in Japan. It inhibited human platelet aggregation ex-vivo induced by collagen, arachidonic acid, ADP, PAF, epinephrine and thrombin. In addition, it inhibited platelet adhesion and release reaction. In animal models of thrombosis, oral administration of a low dose of E5510 inhibited thrombus formation. Studies on its mode of action suggest that E5510 blocks multiple pathways of platelet activation: inhibition of arachidonic acid release, cyclooxygenase and PDE. Using healthy volunteers, inhibition of platelet aggregation was demonstrated with 1 hour after a single dose of E5510 and continued for more than 8 hours. No inhibition was observed 24 hours after administration. E5510 is currently under clinical evaluations in patients with various thrombotic diseases. This paper also describes the results of its clinical trials regarding the efficacy and safety using the patients with essential thrombocythemia.
Related Concept Videos
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

