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Updated: Aug 11, 2026

Protocol for Measuring the Thermal Properties of a Supercooled Synthetic Sand-water-gas-methane Hydrate Sample
Published on: March 21, 2016
Thermodynamics of non-stoichiometric pharmaceutical hydrates
1Chemical Development Department, Centre de Recherches de Vitry sur Seine, 13 Quai Jules Guesdes, 94400 Vitry sur Seine, France. jean-rene.authelin@sanofi-aventis.com
Abstract:
Different physical and mathematical models of non-stoichiometric hydrates derived form previous work in inorganic hydrates are reviewed. A theoretical link between the order of water molecules in the hydrate and the shape of the isotherm is outlined. The comparison of the models with sorption isotherms and structural data of well-known cases from the literature and one in-house case shows that the model can fit many experimental situations and is in good agreement with qualitative assessments of the order in the hydrates.
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