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Related Experiment Videos

A mouse model for S. typhimurium-induced enterocolitis.

Siegfried Hapfelmeier1, Wolf-Dietrich Hardt

  • 1Institute of Microbiology, ETH Hönggerberg, Wolfgang-Pauli-Str. 10, 8093 Zürich, Switzerland.

Trends in Microbiology
|September 6, 2005
PubMed
Summary

Salmonella typhimurium infection causes acute intestinal inflammation. A new mouse model allows detailed study of bacterial and host factors in this Salmonella typhimurium disease.

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Area of Science:

  • Microbiology
  • Immunology
  • Pathogenesis

Background:

  • Salmonella typhimurium is a model pathogen causing disease through host cell manipulation.
  • Type III secreted virulence proteins are key factors in Salmonella typhimurium pathogenesis.
  • Understanding in vivo mechanisms requires robust animal models.

Purpose of the Study:

  • To introduce and validate a new mouse model for studying Salmonella typhimurium-induced acute intestinal inflammation.
  • To enable detailed investigation of bacterial and host contributions to colitis.

Main Methods:

  • Utilized streptomycin-pretreated mice to establish an acute colitis model.
  • Infected mice with Salmonella typhimurium to observe disease development.
  • Focused on dissecting bacterial virulence factors and host responses.

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Main Results:

  • Salmonella typhimurium successfully induced acute colitis in the streptomycin-pretreated mouse model.
  • The model allows for detailed analysis of bacterial and host interactions during infection.
  • This model provides a platform for dissecting the mechanisms of inflammatory disease.

Conclusions:

  • The streptomycin-pretreated mouse model is effective for studying Salmonella typhimurium-induced intestinal inflammation.
  • This model offers unprecedented detail for dissecting bacterial and host factors in disease.
  • It represents a significant advancement for research into acute intestinal inflammation.