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Updated: Aug 16, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
Triketones active against antibiotic-resistant bacteria: synthesis, structure-activity relationships, and mode of
John W van Klink1, Lesley Larsen, Nigel B Perry
1New Zealand Institute for Crop & Food Research Ltd, University of Otago, PO Box 56 Dunedin, New Zealand. vanklinkj@crop.cri.nz
Abstract:
A series of acylated phloroglucinols and triketones was synthesized and tested for activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE) and multi-drug-resistant Mycobacterium tuberculosis (MDR-TB). A tetra-methylated triketone with a C12 side chain was the most active compound (MIC of around 1.0 microg/ml against MRSA) and was shown to stimulate oxygen consumption by resting cell suspensions, suggesting that the primary target was the cytoplasmic membrane.
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