Veterinary applications of cytokines

Jean-Pierre Y Scheerlinck1, Hung-Hsun Yen

  • 1The Centre for Animal Biotechnology, The University of Melbourne, Parkville, Vic. 3010, Australia. j.scheerlinck@unimelb.edu.au

Summary

Veterinary cytokines aid in developing diagnostics and understanding immune protection. Availability of reagents and unique models in veterinary species accelerates their use in human disease research.

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...