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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Investigation of factor Xa inhibitors containing non-amidine S1 elements
Jeffry B Franciskovich1, John J Masters, Jennifer M Tinsley
1Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. j.franciskovich@lilly.com
Bioorganic & Medicinal Chemistry Letters
|September 6, 2005
Abstract:
Several non-amidino S1 derivatives of the 1,2-diaminobenzene-based scaffold (4) were synthesized and evaluated for their ability to bind to the active site and inhibit the human protease factor Xa. A subset of these compounds were also evaluated for their anticoagulant effects in human plasma as measured by prothrombin time (PT).

