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Updated: Aug 16, 2026

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Synthesis, growth inhibition, and cell cycle evaluations of novel flavonoid derivatives
Yerra Koteswara Rao1, Shih-Hua Fang, Yew-Min Tzeng
1Institute of Biotechnology, Chaoyang University of Technology, Wufeng 413, Taiwan, ROC.
Abstract:
As a continuation of our search for potential new anticancer agents, a series of ten flavonoid derivatives has been synthesized by cyclization of substituted chalcones. Target compounds were evaluated for their biological activity. Among them, compounds 1-4 and 9 displayed a significant growth inhibitory action against a panel of tumor cell lines including Jurkat, PC-3, and Colon 205. On treatment with an equitoxic (IC50) concentration, compounds 1-5 and 7-9 blocked cells in the G2/M phase of the Jurkat cell cycle, whereas compound 6 blocked the same in the G0/G1 phase.
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