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Updated: Aug 16, 2026

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
Published on: July 21, 2023
[Effects of beta-blockers on transmitral, pulmonary venous flows, and spontaneous echo-contrast grades in heart
Sait Mesut Doğan1, Mustafa Aydin, Metin Gürsürer
1Department of Cardiology, Medical Faculty, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey.
Objective:
In this study, we aimed to investigate effects of metoprolol treatment on transmitral, pulmonary venous flows and spontaneous echo contrast in patients with heart failure.
Methods:
Twenty-four patients (mean age: 55+/-8 years) with heart failure were enrolled to the study. All were given metoprolol succinate with titrated target dose of 50 mg/d controlled release tablets for 1 month. Transmitral flow and pulmonary venous flow, systolic, diastolic and atrial reversal flow velocities were measured, and compared with the pretreatment values.
Results:
Heart rate significantly decreased. No significant change was observed in ejection fraction. When the post treatment values were compared with the pretreatment values, it was detected that isovolumetric relaxation time significantly decreased (p<0.05), mitral E wave and E/A ratio were significantly increased (p<0.05 and p<0.05, respectively) after the treatment. A significant increase was observed in pulmonary vein systolic velocity after metoprolol treatment (p<0.05).
Conclusion:
Metoprolol treatment can cause an improvement in transmitral and pulmonary venous flows.
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