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[Familial occlusion of central veins associated with type II familial hyperlipoproteinemia]
1Service d'ophtalmologie, Hôpital Jules Gonin, Université de Lausanne.
Insights
Type II hyperlipoproteinaemia is a significant risk factor for central retinal vein occlusions, particularly in younger patients. Early screening of family members is recommended for prompt prophylactic treatment.
Area of Science:
- Ophthalmology
- Genetics
- Metabolic Disorders
Background:
- Central retinal vein occlusion (CRVO) is a serious eye condition.
- Type II hyperlipoproteinaemia is a metabolic disorder characterized by elevated lipid levels.
Observation:
- A family presented with three members across two generations experiencing CRVO.
- Two affected individuals were under 40 years old, suggesting a potential genetic link.
Findings:
- Hyperlipoproteinaemia appears to be a significant risk factor for CRVO.
- CRVO associated with hyperlipoproteinaemia shows higher recurrence rates, poor visual prognosis, and increased incidence in younger patients.
Implications:
- Screening for hyperlipoproteinaemia in young CRVO patients is crucial.
- Early detection and prophylactic hypolipidaemic treatment can be initiated in affected families.
Abstract:
We report, for the first time to the best of our knowledge, about a family in which 3 members (two of which were under 40 years of age) of two successive generations presented central retinal vein occlusions in relation to a type II hyperlipoproteinaemia. On the basis of the reported cases, it can be postulated that hyperlipoproteinaemia seems to be a serious potential risk factor for central retinal vein occlusion. The particular aspects of central vein occlusion in relation to hyperlipoproteinaemia are the elevated frequency of recurrences, the poor visual prognosis secondary to severity of veinous obstruction, and the increased incidence of these occlusions in younger patients. The discovery of a hyperlipoproteinaemia in young patients with central retinal vein occlusion should therefore incite prompt examination of other family members in order to initiate prophylactic hypolipaemic treatment.