Related Experiment Video
Updated: Aug 16, 2026

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
Published on: October 15, 2021
Ancient haplotypes of the HLA Class II region
Christopher K Raymond1, Arnold Kas, Marcia Paddock
1University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
Abstract:
Allelic variation in codons that specify amino acids that line the peptide-binding pockets of HLA's Class II antigen-presenting proteins is superimposed on strikingly few deeply diverged haplotypes. These haplotypes appear to have been evolving almost independently for tens of millions of years. By complete resequencing of 20 haplotypes across the approximately 100-kbp region that spans the HLA-DQA1, -DQB1, and -DRB1 genes, we provide a detailed view of the way in which the genome structure at this locus has been shaped by the interplay of selection, gene-gene interaction, and recombination.
Related Concept Videos
Non-LTR Retrotransposons
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Multiple Allele Traits
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Histone Variants at the Centromere

