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Updated: Aug 16, 2026

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Published on: July 25, 2017
Risk factors associated with the rupture of tubal ectopic pregnancy
Gregory Latchaw1, Peter Takacs, Lucia Gaitan
1Department of Obstetrics and Gynecology, Jackson Memorial Hospital/University of Miami, Miami, FL 33010, USA.
Objective:
To identify risk factors that may lead to the rupture of ectopic pregnancies.
Study Design:
A retrospective chart review was performed on patients with ectopic pregnancies at the University of Miami/Jackson Memorial Hospital between 1/1/1995 and 3/1/2002. 738 patients were identified with ectopic pregnancies. Women with tubal rupture were compared to those without rupture. Variables analyzed were demographic data, patient-related risk factors (history of pelvic surgery, bilateral tubal ligation, history of pelvic inflammatory disease, previous ectopic pregnancy, intrauterine device use) and beta-human chorionic gonadotropin (betahCG) measurement.
Results:
There were 439 (59%) cases with a ruptured and 299 (41%) cases with an unruptured ectopic pregnancy. Multivariate logistic regression analysis revealed that previous ectopic pregnancy (OR 2.88; 95% CI 1.92, 4.33) and betahCG level >or=5,000 mIU/ml (OR 1.85; 95% CI 1.12, 3.06) were the only significant risk factors for tubal rupture.
Conclusion:
Patients with betahCG levels >or=5,000 mIU/ml and patients with a history of a previous ectopic pregnancy are significantly more likely to experience a tubal rupture.
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