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Updated: Aug 16, 2026
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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
[Study of ocular surface involvement in diabetic patients]
C Creuzot-Garcher1, P O Lafontaine, O Gualino
1Service d'Ophtalmologie, Centre Hospitalier Universitaire, Dijon, France. catherine.creuzot-garcher@chu-dijon.fr
Journal Francais D'Ophtalmologie
|September 6, 2005
Summary
Diabetic eye disease significantly impacts corneal nerves and tear production, independent of disease duration or blood sugar control. These ocular surface changes correlate with retinopathy and neuropathy, potentially leading to severe complications.
Area of Science:
- Ophthalmology
- Diabetology
- Neuroscience
Context:
- Diabetes mellitus is a leading cause of microvascular complications, including those affecting the eyes.
- Ocular surface disease is often linked to corneal nerve impairment in diabetic patients.
- The relationship between ocular surface abnormalities and diabetic retinopathy or neuropathy requires further investigation.
Purpose:
- To investigate the association between ocular surface signs and diabetic neurovascular complications.
- To compare corneal sensitivity and tear function in diabetic patients and healthy controls.
- To determine the correlation of disease duration, metabolic control, retinopathy stage, and peripheral neuropathy with ocular surface disorders.
Summary:
- Diabetic patients exhibited significantly altered corneal sensitivity, tear film break-up time, and staining compared to controls.
- Ocular surface abnormalities were not correlated with disease duration or HbA1c levels.
- Reduced corneal sensitivity and impaired tear function were more pronounced in patients with preproliferative retinopathy and peripheral neuropathy.
Impact:
- Diabetes can cause significant ocular surface impairments, including tear film dysfunction.
- These abnormalities are closely linked to the progression of diabetic retinopathy and peripheral neuropathy.
- Undiagnosed lacrimal and corneoconjunctival issues in diabetics may lead to severe neurotrophic complications.
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