Related Experiment Video
Updated: Aug 16, 2026
Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
Published on: September 8, 2023
[Vertebral trabecular network analysis on CT images]
J Lasbleiz1, A Burgun, F Marin
1Département de Radiologie et d'Imagerie Médicale, Hôpital Sud CHU Rennes. jeremy.lasbleiz@chu-rennes.fr
Purpose:
Comparing texture analysis, density measurement and visual quantification of trabecular network on spine CT images, to better evaluate bone architecture in osteoporosis.
Method And Materials:
Seventeen patients, aged 19 to 84 years, were included. One patient presented osteoporotic fractures. High resolution computed tomographic (HR-CT) images of the third lumbar vertebra were acquired using a Somatom 4 plus CT (Siemens) in a strict axial orientation with FOV of 12 cm and slice thickness of 1 mm. The size of the Region Of Interest was 1,6 cm(2). Three analyses were performed on this ROI: Density (in Hounsfield Unity), texture analysis (run length) and features inspired from bone histomorphometry (Bone Volume/Tissue Volume).
Results:
Density measurement, run length methods and BV/TV provided consistent results with regards to age. Indeed density, run length and BV/TV results were lower for older patients with more advanced bone trabeculra alterations.
Conclusion:
Only BV/TV and run length parameters seemed to show additional information on trabecular network architecture. The contribution of these two measurements to diagnose and classify osteoporosis will be the goal of a clinical study.
