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Radiolabelling and biodistribution of 111In-antimony trisulphide colloid
Chris Tsopelas1, Robert Cooper
1RAH Radiopharmacy, Royal Adelaide Hospital, Nuclear Medicine Department, North Terrace, Adelaide, 5000, Australia. ctsopela@mail.rah.sa.gov.au
Abstract:
The aim of this study was to prepare 111In-antimony trisulphide colloid (111In-ATC) and evaluate its chemical properties in comparison with 99mTc-ATC. After reconstitution of an antimony trisulphide cold Kit with 111In-chloride, 111In-ATC was formed with >95% radiochemical purity in the presence of neutralising phosphate buffer. The product was found to be stable for 4.7 days when stored at room temperature, 80% of radioactive particles were < 20 nm in diameter and the mouse biodistribution assay was identical to that of 99mTc-ATC. In conclusion, pharmaceutical-grade 111In-ATC was successfully prepared and assessed to have properties that are suitable for dual-isotope lymphoscintigraphy studies at the clinical level.
