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Rotenoids and isoflavones from Sarcolobus globosus
Helle Wangensteen1, Mahiuddin Alamgir, Sultana Rajia
1Department of Pharmacognosy, School of Pharmacy, University of Oslo, Blindern, Oslo, Norway. helle.wangensteen@farmasi.uio.no
Planta Medica
|September 6, 2005
Summary
This study identifies novel compounds, sarcolobin and sarcolobone, from the Asian medicinal plant Sarcolobus globosus. Several known rotenoids and a unique chromone were also discovered, expanding the known chemical profile of this mangrove species.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Medicinal Botany
Background:
- Sarcolobus globosus is a plant species found in Asian mangrove ecosystems.
- The chemical constituents of Sarcolobus globosus have not been previously reported.
- Mangrove plants are a source of diverse bioactive compounds.
Purpose of the Study:
- To investigate the chemical constituents of Sarcolobus globosus.
- To isolate and identify novel compounds from the plant extract.
- To characterize the phytochemical profile of this medicinal plant.
Main Methods:
- Extraction of Sarcolobus globosus using diethyl ether.
- Isolation and purification of compounds using chromatographic techniques.
- Structure elucidation of isolated compounds using spectroscopic methods.
Main Results:
- Identification of a new rotenoid, sarcolobin.
- Identification of a new isoflavone, sarcolobone.
- Discovery of known rotenoids (tephrosin, 12aalpha-hydroxydeguelin, etc.) and the isoflavone barbigerone.
- Isolation of 6,7-dimethoxy-2,3-dihydrochromone, a novel natural product.
Conclusions:
- Sarcolobus globosus is a rich source of rotenoids and isoflavones.
- The study reports the first known chemical constituents from Sarcolobus globosus.
- A novel chromone derivative was identified, expanding the known natural products.