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Published on: May 10, 2017
In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma
Kyung Ah Koo1, Sang Hyun Sung, Jong Hee Park
1College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea.
Abstract:
Ten phenylethanoid glycosides, forsythoside B, acteoside, 2'-acetylacteoside, poliumoside, brandioside, echinacoside, isoacteoside, cistanoside H and E-tubuloside E as well as a new compound, Z-tubuloside E, were isolated from the n-BuOH fraction of Callicarpa dichotoma Raeuschel (Verbenaceae) by bioactivity-guided fractionation using glutamate-injured primary cultures of rat cortical cells as a screening system. These phenylethanoid glycosides significantly attenuated glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 microM.
