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Studies on lidocaine-induced kindling
1Department of Pharmacology, Baylor College of Dentistry, Dallas, Texas 75246.
Life Sciences
|January 1, 1992
Summary
Pharmacological kindling from lidocaine hydrochloride (HCl) in mice appears to depend more on the total number of injections than their frequency. Doses around 40 mg/kg approached the threshold for inducing kindling.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Lidocaine hydrochloride (HCl) is known to induce pharmacological kindling in rats when administered frequently.
- Understanding the dose-response and frequency-dependence of this effect is crucial for preclinical research.
Purpose of the Study:
- To determine the approximate threshold dose for lidocaine-induced pharmacological kindling in mice.
- To investigate whether a reduced injection frequency impacts the development of kindling.
Main Methods:
- Mice received intraperitoneal injections of lidocaine HCl at doses ranging from 30 to 50 mg/kg.
- Two injection schedules were employed: 5 times weekly for 4 weeks, or 2 times weekly for 10 weeks.
- Kindling was defined as observing convulsions in 5 consecutive injections.
Main Results:
- The estimated threshold dose for kindling was approximately 40 mg/kg, with 2/8 mice kindled at this dose and 8/8 at 50 mg/kg when injected 5 times weekly.
- When administered at 50 mg/kg, 80% of mice were kindled by the 15th injection, regardless of whether injections were given 5 times or twice weekly.
Conclusions:
- Pharmacological kindling in mice appears to be influenced by the cumulative number of injections rather than solely by the frequency of administration.
- The findings suggest that the total exposure, represented by the number of doses, is a key factor in the development of lidocaine-induced kindling.