[Correlation between the polymorphism of HLA-A, -B, and -DRB1 alleles and susceptibility to leukemia]
1Center Laboratory, First Hospital of Lanzhou University, Lanzhou 730000, China. lanxiazhou@hotmail.com
Aim:
To explore the correlation between the polymorphism of HLA-A, -B and -DRB1 alleles and susceptibility to leukemia in Chinese Han population, Gansu province.
Methods:
The polymorphism of HLA-A, -B and -DRB1 alleles in 57 patients with leukemia and 45 normal controls were determined by PCR with sequence-specific oligonucleotide probe (PCR-SSO).
Results:
The frequencies of allele HLA-A01, -B38, and -DR15 in patients with leukemia were higher than those in control group (P<0.05), while the frequencies of allele HLA-A11 and -DR03 notably decreased (P<0.05).
Conclusion:
HLA-A01, -B38 and -DR15 alleles in Han population, Gansu province seem to contribute to the genetic susceptibility, while HLA-A11 and -DR03 alleles to the genetic resistance, to leukemia.
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