[Treatment of respiratory syncytial virus by intravenous gamma-globulin]
Related Experiment Video
Updated: Aug 7, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 11, 2013
Yan-hui Li1, Guo-cheng Zhang, Dong-liang Xu
1Department of Pediatrics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Aim:
To explore in vitro and in vivo the effect of the intravenous gamma-globulin (IVgammaG) on the respiratory syncytial virus (RSV).
Methods:
(1) The microdose cytopathogenic inhibition assay (MCIA) was used to observe the effect of different concentrations of IVgammaG on RSV replication. (2) 40 BALB/c mice were infected with RSV and then randomly divided into four groups: namely, the IVgammaG treatment group, the ribavirin treatment group, the Palivizumab treatment group and the normal saline group (control group). Half of the mice in each group were killed at the fifth day and the seventh day after treatment, respectively, to isolate the virus and perform pathological examination of the lung tissue.
Results:
(1) IVgammaG inhibited RSV replication in vitro. The treatment index (TI) of IVgammaG was 275, which was about 7 times of TI of ribavirin and one third of Palivizumab. (2) The pathological score of the lung tissue in the IVgammaG group was lower than that of control group (P<0.01), but higher than that of Palivizumab group (P<0.05).
Conclusion:
The IVgammaG has an anti-RSV effect both in vivo and in vitro, but its effect is lower than that of Palivizumab.
Related Concept Videos
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Cytomegalovirus Disease
Respiratory Syncytial Virus Disease
Inhibitors of Viral Protein Synthesis

