Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biventricular assist device-induced right ventricular reverse structural and functional remodeling.

Stefan Klotz1, Yoshifumni Naka, Mehmet C Oz

  • 1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|September 7, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Right Ventricular Metrics as End Points in Clinical Trials: A Review.

JAMA cardiology·2026
Same author

Comprehensive clinical benefit of CCM in HFrEF patients: a win-ratio analysis of FIX-HF-5C randomized trial.

ESC heart failure·2026
Same author

Universal Pulmonary Resistance-Compliance Relationship: And Why It Matters?

Circulation. Heart failure·2026
Same author

De Novo Aortic Insufficiency and Its Progression in Patients on Microaxial Flow Pump Support Before Durable Left Ventricular Assist Device.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

Cardiac microcurrent therapy in heart failure: Mechanistic rationale, early clinical evidence, and future directions.

Heart failure reviews·2026
Same author

Does Pacemaker Mode Affect Outcomes in Patients With HeartMate 3 LVAD?

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026

Biventricular assist device (BiVAD) support reverses right ventricular remodeling in heart failure patients. This contrasts with left ventricular assist device (LVAD) support, highlighting the importance of biventricular unloading for complete cardiac recovery.

Area of Science:

  • Cardiovascular Science
  • Medical Engineering
  • Heart Failure Research

Background:

  • Left ventricular assist device (LVAD) support improves left ventricular (LV) function but does not induce reverse remodeling in the right ventricle (RV).
  • The RV remains dilated during LVAD support, and the potential for RV reverse remodeling with RV or biventricular assist device (BiVAD) support is unknown.

Purpose of the Study:

  • To investigate the effects of BiVAD support on right ventricular (RV) structure and function.
  • To compare RV remodeling in patients with BiVAD support versus those with LVAD support or no assist device.

Main Methods:

  • Analysis of explanted hearts from patients with congestive heart failure (CHF), LVAD support, and BiVAD support.
  • Assessment of RV end-diastolic pressure-volume relationships (EDPVRs), chamber stiffness, cardiomyocyte function, histology, and collagen content.

Related Experiment Videos

Main Results:

  • BiVAD support significantly reduced RV size, mass, and myocyte diameter to normal levels compared to non-supported and LVAD-supported hearts.
  • Cardiomyocyte function normalized with BiVAD support, showing improved responses to stimulation and isoproterenol.
  • BiVAD support led to increased myocardial collagen content and chamber stiffness.

Conclusions:

  • Biventricular assist device (BiVAD) support induces significant reverse structural and functional remodeling of the right ventricle.
  • Hemodynamic unloading of both ventricles is crucial for achieving complete cardiac reverse remodeling, unlike LVAD support alone.