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LPS induces stefin A3 expression in mouse primary cultured glial cells
Toru Hosoi1, Sawako Suzuki, Yasunobu Okuma
1Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Brain Research. Molecular Brain Research
|September 7, 2005
Abstract:
We searched for a gene that is up-regulated in response to LPS at a later time point in primary cultured glial cells. Using a Gene Chip Probe Array, we identified stefin A3, which is known as a cysteine protease inhibitor. As assessed by RT-PCR, we observed a time-dependent (2 to 48 h) up-regulation of stefin A3. The results indicate that stefin A3 is involved in infection and inflammation at a later time point.
