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Updated: Aug 16, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Polysulfated sialic acid derivatives as anti-human immunodeficiency virus
Masaki Terada1, Shuji Fujita, Isao Suda
1Central Research Institute, Nissin Food Products Co. Ltd., 2247 Noji-cho, Kusatsu-city, Shiga 525-0055, Japan. macterad@bc4.so-net.ne.jp
Abstract:
We report the synthesis of a novel alkyl polysulfated sialic acid derivative denoted as NMSO3. NMSO3 exhibited potent inhibition against both laboratory and clinical human immunodeficiency virus type 1 (HIV-1). The anti-viral activity of this compound (1 uM) was compared to dextran sulfate (3 uM), and was found to be more potent against HIV-1IIIb than AZT (10 uM). The anti-coagulation time was more than 15-fold shorter than that of dextran sulfate. An in vivo anti-viral study of NMSO3 in NOD-SCID-PBL mice HIV model showed complete protection of the animals from virus challenge at the concentration of 10 mg/kg. This suggests that NMSO3 can be effective in the treatment of HIV-infected individuals.

