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Related Experiment Videos

Influenza immunisation in children with solid tumours.

J Chisholm1, K Howe, M Taj

  • 1Department of Paediatric Oncology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK. chishj@gosh.nhs.uk

European Journal of Cancer (Oxford, England : 1990)
|September 7, 2005
PubMed
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Children with cancer, including solid tumors and lymphoma, show significant immune responses to influenza vaccination. Annual flu shots are recommended to protect these vulnerable children from infection.

Area of Science:

  • Pediatric Oncology
  • Immunology
  • Vaccinology

Background:

  • Children with non-leukaemic malignant diseases, such as solid tumours and lymphoma, are at increased risk of severe influenza infection.
  • Assessing the immunogenicity of influenza vaccination in this immunocompromised population is crucial for public health strategies.

Purpose of the Study:

  • To evaluate the immune response to trivalent split virus influenza vaccine in children with non-leukaemic malignant diseases.
  • To determine the seroprotection and seroresponse rates following influenza vaccination in this patient group.

Main Methods:

  • Prospective assessment of antibody titres (haemagglutination inhibition assay) in children receiving chemotherapy or within six months of completion.
  • Vaccination administered according to UK guidelines in autumn 2001 and/or 2002.

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  • Analysis of pre- and post-vaccination sera for antibodies against prevalent influenza strains (H1N1, H3N2, and B).

    • Main Results:

    • A significant proportion of children were susceptible to circulating influenza strains prior to vaccination (30% to all three).
    • Seroresponse rates (4-fold rise in HI titres) were 52% for H1N1, 33% for H3N2, and 51% for B.
    • Following vaccination, 38% of episodes achieved protective titres against all three viruses, and 19% against one or two viruses.

    Conclusions:

    • Children with solid tumours and lymphoma demonstrate a significant, albeit variable, immune response to influenza vaccination.
    • Influenza vaccination is well-tolerated and recommended for annual administration in children with non-leukaemic malignant diseases to enhance protection.