A new role for an old hormone: is gastrin a cofactor for dietary metal ion uptake?
1Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia.
Abstract:
It is proposed that gastrin promotes the uptake of divalent and trivalent metal ions from the gastrointestinal lumen by catalyzing the binding of metal ions to luminal albumin and transferrin respectively. The following observations are consistent with this hypothesis: 1. Gastrin binds both divalent and trivalent metal ions. 2. Gastrin binds to both albumin and apotransferrin. 3. Binding of gastrin to albumin is enhanced by divalent metal ions. 4. Gastrin, albumin and transferrin are all present in gastric juice. 5. Surgical removal of the gastric mucosa results in iron deficiency.
More Related Videos
10:34Essential Metal Uptake in Gram-negative Bacteria: X-ray Fluorescence, Radioisotopes, and Cell Fractionation
Published on: February 1, 2018
07:26Metal-Limited Growth of Neisseria gonorrhoeae for Characterization of Metal-Responsive Genes and Metal Acquisition from Host Ligands
Published on: March 4, 2020
Related Concept Videos
Hormonal Regulation
Introduction to Electrolytes
Role of Sodium
One...
Extraction: Advanced Methods
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds to M3...
Mucosal Barrier of the Stomach
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Gastritis II: Pathophysiology
