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Updated: Jul 26, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
Published on: January 16, 2019
Use of the single subject design for practice based primary care research
1University of Pittsburgh, School of Medicine, Department of Family Medicine and Clinical Epidemiology, and the Center for Primary Care Community-Based Research, 3518 Fifth Avenue, Pittsburgh, PA 15261, USA. jej@pitt.edu
Abstract:
The use of a single subject research design is proposed for practice based primary care research. An overview of the rationale of the design, an introduction to the methodology, strengths, limitations, a sample of recent literature citations, a working example, and possible clinical applications are presented.
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