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Relationship between left ventricular dysfunction and depression following myocardial infarction: data from the

Joost P van Melle1, Peter de Jonge, Johan Ormel

  • 1Department of Cardiology, Thorax Centre, University Medical Centre Groningen, The Netherlands. j.p.van.melle@med.umcg.nl

European Heart Journal
|September 7, 2005
PubMed

Insights

Depression after myocardial infarction (MI) is linked to worse outcomes. This study found that reduced left ventricular ejection fraction (LVEF) in MI patients correlates with higher rates and severity of depression.

Area of Science:

  • Cardiology
  • Psychiatry
  • Clinical Research

Background:

  • Depression following myocardial infarction (MI) is linked to increased mortality.
  • This association may be confounded by the severity of cardiac disease.

Purpose of the Study:

  • To explore the relationship between left ventricular ejection fraction (LVEF) and depression in patients post-MI.

Main Methods:

  • The Myocardial Infarction and Depression-Intervention Trial (MIND-IT) assessed 1989 MI patients for depressive symptoms using the Beck Depression Inventory (BDI).
  • Patients with BDI scores >= 10 were evaluated for International Classification of Diseases, 10th revision (ICD-10) depressive disorder.
  • Patients were categorized by LVEF (<30%, 30-45%, 45-60%, > or = 60%).

Main Results:

  • Depressive symptoms were more prevalent in patients with left ventricular (LV) dysfunction during hospitalization.
  • A significant inverse relationship was observed between LVEF and depression rates (ICD-10) from 3 to 12 months post-MI (P < 0.01).
  • Lower LVEF inversely correlated with BDI scores at 3 months post-MI, persisting after adjustments.

Conclusions:

  • The rate and severity of depression in MI patients are significantly associated with the severity of LV dysfunction.
  • This link between depression and LV dysfunction is crucial for interpreting the prognostic impact of depression in cardiac patients.
Abstract

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