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Updated: Aug 7, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks
Published on: September 5, 2014
Co-crystallization of hemimellitic acid with 4,4'-bipyridine forming a pillar-layered hydrogen-bonded network
Miao Du1, Zhi-Hui Zhang, Yan-Ping You
1College of Chemistry and Life Sciences, Tianjin Normal University, Tianjin 300074, People's Republic of China. dumiao@public.tpt.tj.cn
Abstract:
Co-crystallization of hemimellitic acid (benzene-1,2,3-tricarboxylic acid) dihydrate (H3HMA.2H2O) with 4,4'-bipyridine (4,4'-bpy) affords the 1:1 co-crystal benzene-1,2,3-tricarboxylic acid-4,4'-bipyridine (1/1), H3HMA.4,4'-bpy or C9H6O6.C10H8N2. Strong O-H...O hydrogen bonds connect the acid molecules to form a one-dimensional zigzag chain, around which the 4,4'-bpy components are fixed as arms via O-H...N interactions, resulting in a ladder motif. Through weak C-H...O non-covalent forces, the resulting acid layers are extended into a three-dimensional pillar-layered architecture supported by rod-like 4,4'-bpy components. The influence on hydrogen-bonding models is also discussed, with the discovery of an unexpected interaction motif that does not follow the routine hydrogen-bonded hierarchical rule in the construction of an acid-base co-crystal.
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