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Updated: Aug 16, 2026
A Modified Surgical Technique for Kidney Transplantation in Mice
Published on: July 22, 2022
[Living donor kidney transplantation in pediatric recipients]
M P Luque Gálvez1, L Peri Cusi, J M Corral Molina
1Servicio de Neurología, Unidad Trasplante Renal, Hospital Clínico de Barcelona, España.
Insights
Kidney transplantation offers superior survival and development in children with end-stage renal disease compared to dialysis. Living donor transplants provide better outcomes, though complications and graft survival factors require careful management.
Area of Science:
- Pediatric Nephrology
- Transplantation Medicine
- Renal Replacement Therapy
Context:
- End-stage renal disease (ESRD) in children necessitates effective treatment strategies.
- Kidney transplantation is the preferred modality for pediatric ESRD, surpassing dialysis in survival and developmental outcomes.
- Transplantation indications have broadened, now encompassing ESRD cases unresponsive to conservative management.
Purpose:
- To review the current status and outcomes of kidney transplantation in pediatric patients.
- To highlight the advantages of living donor kidney transplantation in children, particularly those under two years old.
- To discuss potential complications and factors influencing graft survival in pediatric kidney recipients.
Summary:
- Kidney transplantation demonstrates improved survival rates and promotes better physical and psychosocial development in children with ESRD.
- Living donor kidney transplants offer superior long-term graft survival compared to cadaver donor transplants in pediatric recipients.
- Key complications include rejection, hypertension, infections, and drug-related adverse events, with graft survival influenced by recipient age, pre-transplant dialysis, acute rejection, and race.
Impact:
- Advances in pediatric kidney transplantation have significantly improved patient outcomes and quality of life over the past five decades.
- Mortality rates have decreased to below 5%, with five-year graft survival reaching up to 90% for living donor kidneys.
- Understanding factors affecting graft survival is crucial for optimizing treatment protocols and improving long-term success in pediatric kidney transplantation.
Abstract:
Currently, kidney transplantation is the treatment of choice in children with end stage renal disease, showing higher survivals than dialysis and proper weight-height, social and psychological-intellectual development. The indications for transplantation have been extended with time, so that today the indication for kidney transplantation is set for end stage renal disease with symptoms that cannot be eliminated by conservative treatment. In the pediatric age, mainly in children under two years, living donor kidney transplantation is specially indicated because it has longer survival than cadaver donor kidneys. Complications may appear: rejection, high blood pressure, infections, neoplasias, adverse events related to immunosuppressive drugs, and primary renal disease recurrences, besides surgical complications. Five-year results have improved over the last 5 decades, being mortality lower than 5%. Graft survival may reach 90% for living donor kidneys and 17% for cadaver donor. Factors related to graft survival include age (worse in receptors under 2 yr.), pretransplant dialysis, acute rejection, and race (better in caucasians).
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