Related Experiment Video
Updated: Aug 16, 2026

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
Published on: May 5, 2022
The prognostic value of a QRS score during exercise testing
Andreas P Michaelides1, Maria-Niki K Aigyprladou, George K Andrikopoulos
1Exercise Laboratory, Department of Cardiology, A' Cardiology Clinic, Medical School of Athens University, Hippokration Hospital, Athens, Greece. aigyptiadou@yahoo.gr
Insights
An abnormal QRS score during treadmill exercise testing is a significant predictor of cardiac mortality in patients with coronary artery disease (CAD). This finding highlights the QRS score's clinical value in predicting outcomes for individuals with established CAD.
Area of Science:
- Cardiology
- Exercise Physiology
- Diagnostic Imaging
Background:
- QRS score values correlate with coronary artery narrowing and myocardial ischemia extent.
- Radionuclide imaging techniques have previously shown this association.
Purpose of the Study:
- To assess the prognostic capability of abnormal QRS scores from treadmill exercise tests.
- To investigate the predictive value of QRS scores in patients with established coronary artery disease (CAD).
Main Methods:
- 309 patients with documented CAD underwent treadmill exercise testing and coronary arteriography.
- Patients were prospectively followed for up to 36 months.
Main Results:
- Abnormal QRS scores (<= -4) were significantly and independently linked to cardiac mortality.
- A relative risk of 11.7 (p=0.002) was observed for cardiac mortality with abnormal QRS scores.
Conclusions:
- The QRS score holds clinical utility in predicting outcomes for patients with documented CAD.
- Incorporating the QRS score into exercise testing can aid in managing ischemic heart disease.
Background:
Values of a QRS score have been positively related to the number of narrowed coronary arteries and to the extent of myocardial ischemia in radionuclide imaging techniques.
Hypothesis:
This study was conducted to evaluate the potential prognostic information of abnormal values of this QRS score during treadmill exercise testing in patients with established coronary artery disease (CAD).
Methods:
In all, 309 patients (258 men, 51 women, mean age 56.1 +/- 10.0 years) with documented CAD, underwent a treadmill exercise test and coronary arteriography at baseline. Subsequently, they were prospectively followed to a maximum of 36 months (mean follow-up 23 +/- 13 months, median 25 months).
Results:
During the follow-up period, 20 patients (6.5%) died from acute myocardial infarction. Abnormal QRS score values were found to be significantly and independently associated with cardiac mortality (QRS < or = -4: relative risk 11.7; 95% confidence interval = 2.5-55.4; p = 0.002).
Conclusions:
Taking into consideration the importance of exercise testing in the management of ischemic heart disease, the use of this QRS score could be of clinical value in predicting the outcome of patients with documented CAD.
Related Concept Videos
Electrocardiogram
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and the T...
Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
ECG Interpretation of Rhythms
Components of the Electrocardiogram
The primary components of a normal ECG waveform in Normal sinus rhythm(NSR) include the P wave, PR interval, QRS complex, ST segment, T wave, and occasionally a U wave.
ECG waveforms are divided by vertical and horizontal lines at standard intervals.
The horizontal axis measures time and rate, and the vertical axis measures amplitude or voltage. When...
Correlation between ECG and Cardiac Cycle
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
Acute Coronary Syndrome III: Diagnostic Studies
Electrocardiogram Fundamentals
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin to...