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Circulating resistin concentrations in children depend on renal function

Kai-Dietrich Nüsken1, Jürgen Kratzsch, Veronica Wienholz

  • 1Klinik für Kinder und Jugendliche, University of Erlangen-Nürnberg, Erlangen, Germany.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|September 8, 2005
PubMed

Insights

Serum resistin levels increase in children with declining renal function, particularly in end-stage renal disease patients undergoing haemodialysis. Age may also influence these elevated resistin concentrations in pediatric renal impairment.

Area of Science:

  • Pediatric Endocrinology
  • Nephrology
  • Metabolic Research

Background:

  • Resistin is a peptide hormone implicated in adipogenesis, insulin resistance, and inflammation.
  • The precise physiological role of resistin in humans remains largely undefined.
  • Investigating resistin's regulation by renal function in children is crucial for understanding its role in pediatric health.

Purpose of the Study:

  • To investigate the relationship between serum resistin concentrations and renal function in children.
  • To determine if renal impairment influences resistin levels in a pediatric cohort.

Main Methods:

  • Serum resistin concentrations were measured using ELISA in 15 pediatric patients with end-stage renal disease on haemodialysis (HD), 11 with chronic renal failure (CRF), and 23 healthy children.
  • Glomerular filtration rate (GFR), body mass index (BMI), and age were recorded for all participants.
  • Leptin levels were measured by RIA for comparative analysis.

Main Results:

  • Resistin concentrations were significantly elevated in children with HD and CRF compared to healthy controls (P<0.0001).
  • A trend towards higher resistin levels was observed in the youngest and oldest age groups.
  • Serum resistin levels did not correlate with gender or BMI, and haemodialysis did not significantly reduce resistin concentrations.

Conclusions:

  • Serum resistin concentration is elevated in children with decreased renal function.
  • Age may be a potential factor influencing circulating resistin levels in pediatric populations.
  • Further research is needed to explore the link between elevated resistin, malnutrition, and reduced BMI in children with renal disease.
Abstract

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