Use of paired serum samples for serodiagnosis of typhoid fever

Deborah House1, Nguyen T Chinh, To S Diep

  • 1Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College London, South Kensington, UK. d.house@ic.ac.uk

Using an enzyme-linked immunosorbent assay we demonstrate that, in adult patients with typhoid fever, the sensitivity of a serological test based on the detection of anti-lipopolysaccharide immunoglobulin G is increased when used with paired serum samples taken 1 week apart.

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