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[Glucocorticoid-induced osteoporosis: review and proposition for prevention and treatment guidelines]

Simeon Grazio1, Mirko Korsić, Branimir Anić

  • 1Klinika za reumatologiju, fizikalnu medicinu i rehabilitaciju Medicinskog fakulteta SveuMilista u Zagrebu, KB Sestre milosrdnice, Zagreb.

Lijecnicki Vjesnik
|September 9, 2005
PubMed

Insights

Glucocorticoids frequently cause secondary osteoporosis by harming bone cells, leading to lower bone density and higher fracture risk. Prevention involves lifestyle changes, supplements, and bisphosphonate medications for high-risk patients.

Area of Science:

  • Endocrinology and Bone Metabolism
  • Pharmacology of Glucocorticoids

Context:

  • Glucocorticoids are a leading cause of secondary osteoporosis.
  • These drugs negatively impact bone quantity and quality, particularly osteoblast function.

Purpose:

  • To review the effects of glucocorticoids on bone health.
  • To outline strategies for preventing and managing glucocorticoid-induced osteoporosis and fractures.

Summary:

  • Glucocorticoid use decreases bone mineral density and elevates fracture risk, especially in postmenopausal women.
  • Prevention strategies include minimizing glucocorticoid dosage, calcium/vitamin D supplementation, hormone therapy, and physical activity.
  • Bisphosphonates are recommended as first-line treatment for patients at high risk of osteoporosis.

Impact:

  • Highlights the significant skeletal risks associated with glucocorticoid therapy.
  • Provides a comprehensive overview of preventative measures and therapeutic options for glucocorticoid-induced bone loss.
  • Emphasizes the importance of early intervention with antiresorptive drugs like bisphosphonates.

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