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[Preventive effect of 5-fluorouracil on post-ERCP pancreatitis]
Wen-Tao Fan1, Qun-Wei Wang, Qing-Long Li
1Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha 41001 1, China. fanwentao2002@yahoo.com.cn
Objective:
To investigate the preventive effect of 5-fluorouracil (5-FU) on post-ERCP (endoscopic retrograde cholangiopancreatography) hyperamy-lasemia and pancreatitis.
Methods:
One hundred and sixty patients who underwent ERCP were divided at random into 2 groups: group A (n = 80) was given meglumine diatrizoate with 5-FU; and group B (n = 80) was used contrast medium without 5-FU. Blood was drawn in each group the day before, 6 hours and 24 hours following ERCP for amylase.
Results:
Post-ERCP hyperamylasemia occurred in 9 patients in group A (11. 25%) and 45 in B (56.25%). The difference of both groups was notable. Pancreatitis ensued in 2 instances in group A (2.50%) and 8 in group B (10.00%). Their difference was significant.
Conclusion:
5-FU added in meglumine diatrizoate is helpful to prevent post-ERCP hyperamylasemia and pancreatitis.
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Chronic Pancreatitis II: Collaborative Care
Assessment:
Acute Pancreatitis I: Introduction
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management