Related Experiment Video

Updated: Aug 16, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

[Related inflammation markers among different types of coronary heart disease]

Ying Luo1, Xiu-Mei Xie, Hui-Xia Liu

  • 1Department of Gerontology, Xiangya Hospital, Central South University, Changsha, China. XLYL@medmail.com

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|September 9, 2005
PubMed

Insights

Activity of NF-kappaB p65, soluble intercellular adhesion molecule-1 (sICAM-1), and C-reactive protein are elevated in acute coronary syndromes, indicating plaque instability. These markers are not affected by the acute event itself.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Biochemistry

Context:

  • Coronary heart disease (CHD) involves plaque instability.
  • Understanding the molecular markers associated with CHD is crucial for risk stratification.

Purpose:

  • To investigate the relationship between NF-kappaB p65 activity, plasma sICAM-1, C-reactive protein, plaque stability, and different types of CHD.
  • To assess the dynamic changes of these markers in relation to acute cardiac events.

Summary:

  • Baseline levels of NF-kappaB p65 activity, sICAM-1, and C-reactive protein were significantly higher in patients with acute myocardial infarction and unstable angina compared to stable angina and controls.
  • While C-reactive protein levels decreased significantly after 3 months in all groups, NF-kappaB p65 activity and sICAM-1 levels remained unchanged.
  • These findings suggest that NF-kappaB p65 and sICAM-1 are not acutely affected by the cardiac event but are linked to plaque stability in CHD.

Impact:

  • Identifies NF-kappaB p65, sICAM-1, and C-reactive protein as potential biomarkers for assessing plaque stability in various forms of coronary heart disease.
  • Suggests that NF-kappaB p65 and sICAM-1 may serve as important risk factors for the development of acute coronary syndromes.
  • Provides insights into the inflammatory pathways involved in the pathogenesis of coronary artery disease.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...