Neurological deficit from metastatic low grade liposarcoma.

Area of Science:

• Oncology
• Pathology
• Radiology

Background:

• Myxoid liposarcoma is a soft tissue malignancy with typically indolent behavior.
• Extrapulmonary metastasis is possible, though rare.
• Pure myxoid liposarcoma without round cell morphology is exceptionally uncommon.

Observation:

• A 47-year-old Thai male presented with metastatic pure myxoid liposarcoma to the thoracic vertebrae.
• The metastasis occurred one year after the primary tumor diagnosis on the left thigh.
• Histological examination of both primary and metastatic sites revealed only the myxoid pattern, lacking round cell features.

Findings:

• This case represents an extremely rare instance of metastatic pure myxoid liposarcoma.
• The absence of round cell morphology in both primary and metastatic lesions is noteworthy.
• This finding challenges the typical understanding of liposarcoma aggressiveness.

Implications:

• This case expands the understanding of metastatic patterns in myxoid liposarcoma.
• It underscores the importance of considering pure myxoid liposarcoma in differential diagnoses of metastatic bone lesions.
• Further research may elucidate the specific biological factors contributing to metastasis in these indolent tumors.