Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

DAX1 origin, function, and novel role.

K K Niakan¹, E R B McCabe

¹Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Molecular Genetics and Metabolism

|September 9, 2005

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Corrigendum to Universal newborn screening: A roadmap for action molecular genetics and metabolism 124 (2018) 177-183.

Molecular genetics and metabolism·2019

Same author

Universal newborn screening: A roadmap for action.

Molecular genetics and metabolism·2018

Same author

Completely self-contained cell culture system: from storage to use.

Molecular genetics and metabolism·2006

Same author

Zebrafish dax1 is required for development of the interrenal organ, the adrenal cortex equivalent.

Molecular endocrinology (Baltimore, Md.)·2006

Same author

Mouth cell collection device for newborn mice.

Molecular genetics and metabolism·2006

Same author

Gene therapy for murine glycerol kinase deficiency: importance of murine ortholog.

Biochemical and biophysical research communications·2005

Same journal

Re: "Disease or non-disease - about the identification of metabolic conditions that require no treatment".

Molecular genetics and metabolism·2026

Same journal

Accessibility and harmonization of biochemical tests for diagnosis and monitoring of Porphyrias in the United States: Recommendations by members of the American Porphyrias Expert Collaborative (APEX).

Molecular genetics and metabolism·2026

Same journal

Participants with long-chain 3-hydroxy-acylCoA dehydrogenase deficiency (LCHADD)/trifunctional protein deficiency (TFPD) report consistent low-fat diet intake over time.

Molecular genetics and metabolism·2026

Same journal

Expanding the clinical and molecular spectrum of NGLY1 deficiency: A multicenter cohort.

Molecular genetics and metabolism·2026

Same journal

Driving treatment for females with X-linked adrenoleukodystrophy.

Molecular genetics and metabolism·2026

Same journal

High dietary fat causes muscle structural breakdown, mitochondrial dysfunction, and contractile deficits in the absence of carnitine palmitoyltransferase 2.

Molecular genetics and metabolism·2026

See all related articles

The DAX1 (dosage sensitive sex-reversal, adrenal hypoplasia congenita critical region on the X-chromosome, gene 1) protein is crucial for adrenal gland development. Emerging research suggests DAX1 also plays a vital role in embryonic development and maintaining stem cell pluripotency.

Area of Science:

Endocrinology
Developmental Biology
Molecular Genetics

Background:

The orphan nuclear receptor NR0B1 encodes the DAX1 protein.
DAX1 is essential for adrenal gland formation and steroidogenic axis development.
DAX1 is linked to dosage sensitive sex-reversal and adrenal hypoplasia congenita.

Purpose of the Study:

To review the known functional roles of DAX1.
To explore hypothesized functions of DAX1 in embryonic development.
To examine DAX1's role in maintaining embryonic stem cell pluripotency.

Main Methods:

Literature review of existing studies on DAX1 and its murine ortholog, Dax1.
Analysis of reports on alternatively spliced variants of DAX1 in humans.
Synthesis of current hypotheses regarding DAX1 function.

Related Experiment Videos

Main Results:

DAX1 is critical for the development and maintenance of the adult adrenal gland.
Evidence suggests Dax1 has roles beyond steroidogenesis, including embryonic development.
DAX1 may be involved in maintaining the pluripotency of embryonic stem cells.

Conclusions:

DAX1 has established roles in adrenal and steroidogenic development.
DAX1 exhibits novel functions in embryonic development and stem cell biology.
Further research is warranted to fully elucidate the multifaceted roles of DAX1.