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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

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Published on: January 7, 2019

Viral vectors for cancer immunotherapy

Richard Harrop1, Miles W Carroll

  • 1Oxford BioMedica Ltd., Oxford Science Park, Oxford, OX4 4GA, United Kingdom.

Frontiers in Bioscience : a Journal and Virtual Library
|September 9, 2005
PubMed

Insights

Cancer immunotherapy is advancing with viral vectors delivering tumor antigens. These viral systems show promise for potent, targeted antitumor responses, moving from pre-clinical to clinical development.

Area of Science:

  • Oncology
  • Immunology
  • Virology

Background:

  • Immunotherapy has gained traction for cancer treatment, spurred by successes in antibody and cytokine therapies.
  • Identifying tumor-associated antigens (TAAs) allows for targeted immunotherapies, reducing autoimmune concerns.
  • Effective cancer vaccines require robust antigen delivery systems.

Purpose of the Study:

  • To review the progress and clinical development of viral vectors for cancer immunotherapy.
  • To highlight the importance of antigen delivery systems in cancer vaccine development.

Main Methods:

  • Review of pre-clinical and clinical studies involving oncolytic viruses and recombinant viral vectors.
  • Focus on viral vectors engineered to deliver TAAs or therapeutic genes.

Main Results:

  • Viral vectors can induce potent and targeted antitumor immune responses.
  • Numerous recombinant viral vectors have advanced from pre-clinical research to clinical trials.
  • These viral systems are crucial for developing novel cancer immunotherapies.

Conclusions:

  • Viral vector-based cancer immunotherapies represent a significant area of ongoing research and development.
  • The use of viruses as delivery systems for TAAs is a key strategy in modern cancer vaccine design.

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