Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Homing genes, cell therapy and stroke.

Woei-Cherng Shyu1, Yih-Jing Lee, Demeral David Liu

  • 1Neuro-Medical Scientific Center, Tzu-Chi Buddhist General Hospital, Tzu-Chi University, Hualien, Taiwan.

Frontiers in Bioscience : a Journal and Virtual Library
|September 9, 2005
PubMed
Summary

Bone marrow-derived stem cells (BMSCs) show promise for stroke treatment by migrating to damaged brain tissue. Their plasticity and function depend on the ischemic micro-environment

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic potential of adipose-derived stem cell transplantation in amyotrophic lateral sclerosis: A combined clinical case and preclinical study.

Tzu chi medical journal·2026
Same author

RETRACTED: Yen et al. <i>n</i>-Butylidenephthalide Regulated Tumor Stem Cell Genes EZH2/AXL and Reduced Its Migration and Invasion in Glioblastoma. <i>Int. J. Mol. Sci.</i> 2017, <i>18</i>, 372.

International journal of molecular sciences·2026
Same author

Essential Pharmacokinetics and Pharmacodynamics of Naringenin: Underpinning the Cardioprotective Potential of Citrus-Based Traditional Medicine.

Archiv der Pharmazie·2026
Same author

<i>Astragalus</i> and <i>Cordyceps</i> Derivatives in the Treatment of Aging-Related Chronic Diseases and Neurodegenerative Disorders.

International journal of molecular sciences·2026
Same author

Variability in epilepsy polygenic risk prediction across Taiwanese population and clinical cohorts.

Epilepsia·2026
Same author

HIF-1α attenuates ferroptosis-associated dermal fibroblast senescence via modulation of NF-κB-DPP4 signaling.

Journal of translational medicine·2026

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Stem cell therapies, including bone marrow transplantation, offer potential for stroke treatment.
  • Bone marrow-derived stem cells (BMSCs), encompassing hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), exhibit significant differentiation and repair capabilities across various organs.
  • Ischemia triggers BMSC mobilization, where stem cells migrate to injury sites and differentiate, influenced by the local micro-environment.

Purpose of the Study:

  • To review the mechanisms by which BMSCs interact with cerebral ischemic tissues.
  • To explore the role of stem cell plasticity in stroke recovery.
  • To highlight the importance of the ischemic micro-environment in regulating BMSC behavior.

Main Methods:

Related Experiment Videos

  • Review of recent scientific literature on stem cell therapy for stroke.
  • Analysis of studies investigating BMSC migration, differentiation, and plasticity in ischemic conditions.
  • Examination of molecular signaling pathways involved in BMSC-tissue interactions, such as SDF-1/CXCR4.

    • Main Results:

    • BMSCs possess the ability to differentiate and promote structural/functional repair in damaged tissues, including the brain.
    • The ischemic micro-environment plays a crucial role in guiding BMSC homing, survival, and differentiation.
    • Specific molecular signals, like SDF-1/CXCR4, mediate the interaction between BMSCs and damaged host tissues.

    Conclusions:

    • Understanding the molecular basis of stem cell plasticity in response to ischemic signals is key for advancing stroke management.
    • BMSC behavior within the brain's ischemic environment is critical for tissue remodeling and repair.
    • Further research into these interactions could lead to improved therapeutic strategies for stroke and other ischemic disorders.