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Noninvasive thermometry using hyperfine-shifted MR signals from paramagnetic lanthanide complexes.

S K Hekmatyar1, R M Kerkhoff, S K Pakin

  • 1Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, USA.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
|September 9, 2005
PubMed
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Paramagnetic lanthanide complexes offer enhanced temperature sensitivity for MR thermometry, overcoming limitations of water-based methods. Thulium complexes show particular promise for in vivo temperature mapping in animal studies.

Area of Science:

  • Biomedical Engineering
  • Magnetic Resonance Imaging
  • Chemical Physics

Background:

  • Current MR thermometry using water 1H signals has limitations in temperature sensitivity and is affected by motion and susceptibility variations, hindering hyperthermia applications.
  • Paramagnetic lanthanide complexes (Pr3+, Yb3+, Tm3+) exhibit significantly higher temperature dependence (up to 300-fold) compared to water signals.
  • These lanthanide complexes offer chemical shifts insensitive to concentration, pH, and ionic variations, improving reliability.

Purpose of the Study:

  • To evaluate the potential of paramagnetic lanthanide complexes for advanced MR thermometry.
  • To identify lanthanide complexes with superior temperature sensitivity and stability for in vivo applications.
  • To assess the feasibility of using these complexes for temperature mapping in biological systems.

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Main Methods:

  • Investigated 1H NMR signals from various paramagnetic lanthanide complexes, including Pr3+, Yb3+, and Tm3+.
  • Assessed the temperature dependence and stability of chemical shifts in the presence of biological factors.
  • Demonstrated applications in intact animals and phantoms for temperature measurement and mapping.

Main Results:

  • Lanthanide complexes showed substantially greater temperature sensitivity than water-based MR thermometry.
  • Thulium 1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTMA-) emerged as a highly promising agent due to intense signals and high temperature sensitivity.
  • Successful imaging of TmDOTMA2- in intact animals at safe concentrations was demonstrated.

Conclusions:

  • MR thermometry utilizing hyperfine-shifted signals from paramagnetic lanthanide complexes holds significant promise for animal research applications.
  • Further research is required to optimize dosage and signal-to-noise ratio for potential clinical translation.
  • TmDOTMA- represents a leading candidate for future in vivo MR thermometry development.