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Use of proteomic patterns as a novel screening tool in pre-eclampsia

Jenny Myers1, Maureen Macleod, B Reed

  • 1Maternal and Fetal Health Research Centre, St Mary's Hospital, University of Manchester, Manchester, UK. jenny.myers@man.ac.uk

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
|September 9, 2005
PubMed

This pilot study aimed to use Ciphergen ProteinChip technology to determine differences in protein profiles in plasma, taken at 26 weeks, from women at risk of developing pre-eclampsia. Five proteins were found to be significantly up-regulated in samples from women who subsequently developed pre-eclampsia compared with women who remained normotensive.

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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...