[Processes of absorption and utilization of glucose in newborn infants with intrauterine hypotrophy]

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Published on: November 15, 2019

V F Demin, M F Deshchekina, A Iu Kostenko

    Pediatriia
    |January 1, 1992
    PubMed

    Insights

    Neonates with intrauterine hypotrophy show increased glucose absorption and delayed utilization. This suggests pancreatic insufficiency in affected infants, impacting glucose metabolism.

    Area of Science:

    • Neonatology
    • Endocrinology
    • Metabolic Disorders

    Background:

    • Intrauterine hypotrophy (IH) poses significant health risks to neonates.
    • Understanding glucose metabolism is crucial for assessing neonatal health.
    • Glucose tolerance testing is a standard diagnostic tool.

    Purpose of the Study:

    • To investigate glucose absorption and utilization in neonates with intrauterine hypotrophy.
    • To evaluate pancreatic function in IH neonates using glucose tolerance test data.

    Main Methods:

    • Glucose tolerance tests were performed on 75 neonates with IH and 19 healthy controls.
    • Analysis focused on glucose absorption rates and utilization patterns.

    Main Results:

    • IH neonates exhibited significantly increased glucose absorption.
    • A notable retardation in glucose utilization was observed in IH neonates.
    • Elevated blood glucose levels at 2 hours post-test indicated impaired glucose handling.

    Conclusions:

    • Intrauterine hypotrophy is associated with altered glucose absorption and utilization.
    • Findings suggest functional insufficiency of the pancreas in neonates with IH.
    • These metabolic disturbances highlight the need for closer monitoring of IH neonates.

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