Related Experiment Video

Updated: Jul 28, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

[Problem of infection in fetuses and newborn infants]

V G Nazarov, V B Mysiakov, S V Zykov

    Pediatriia
    |January 1, 1992
    PubMed

    Insights

    Most neonatal infections are acquired before or during birth, often through ascending pathways. Early clinical and postnatal screening tests are crucial for timely diagnosis in newborns.

    Area of Science:

    • Neonatal infections
    • Perinatal pathology
    • Infectious disease epidemiology

    Context:

    • Analysis of 76 birth histories, neonatal case reports, and autopsy protocols.
    • Focus on infections in neonates leading to mortality.
    • Investigating the timing and route of infection acquisition.

    Purpose:

    • To determine the primary sources and pathways of neonatal infections.
    • To highlight the importance of diagnostic screening tests.
    • To understand the epidemiology of perinatal infections.

    Summary:

    • The majority of neonatal infections were acquired antenatally or during birth.
    • Ascending infection pathways were the predominant route of transmission.
    • Clinical and postnatal screening tests aid in diagnosis.

    Impact:

    • Informs strategies for preventing perinatal infections.
    • Emphasizes the need for early diagnostic interventions.
    • Contributes to reducing neonatal mortality from infections.

    More Related Videos

    A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis08:46

    A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

    Published on: August 12, 2020

    Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice04:18

    Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

    Published on: October 10, 2025

    Related Concept Videos

    Infection01:20

    Infection

    When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
    The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
    Factors Affecting the Risk of Infection01:26

    Factors Affecting the Risk of Infection

    The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
    The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
    Healthcare Associated Infections II: Preventive Measures01:22

    Healthcare Associated Infections II: Preventive Measures

    Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
    The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
    Teratogenicity01:07

    Teratogenicity

    The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
    Development of Immunocompetence01:22

    Development of Immunocompetence

    The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
    The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
    Subsequent T...
    Development of the Oral Microbiota01:28

    Development of the Oral Microbiota

    The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...