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The pathophysiology of the growth plate in juvenile idiopathic arthritis

V E MacRae1, C Farquharson, S F Ahmed

  • 1Bone Biology Group, Roslin Institute, Edinburgh, UK.

Rheumatology (Oxford, England)
|September 9, 2005
PubMed

Insights

Children with chronic inflammatory diseases like juvenile idiopathic arthritis experience growth issues due to increased inflammatory cytokines affecting bone growth locally and systemically.

Area of Science:

  • Pediatric Rheumatology
  • Endocrinology
  • Cell Biology

Background:

  • Chronic inflammatory diseases in children, including juvenile idiopathic arthritis (JIA), are linked to significant growth disturbances.
  • These disorders manifest as generalized growth retardation or localized growth acceleration in affected limbs.

Purpose of the Study:

  • To review the impact of chronic inflammation on childhood growth disorders.
  • To explore the mechanisms by which proinflammatory cytokines affect growth plates and systemic growth.
  • To discuss the interplay between inflammatory and growth-signaling pathways.

Main Methods:

  • Literature review of studies on pediatric growth disorders and inflammation.
  • Analysis of research on cytokine effects on bone growth plates.
  • Examination of evidence for cross-talk between inflammatory and growth pathways.

Main Results:

  • Proinflammatory cytokines are implicated in both general growth retardation and local growth abnormalities in children with chronic inflammatory conditions.
  • Both local effects on growth plates and systemic influences contribute to these growth disorders.
  • Evidence suggests significant interactions between inflammatory cytokine signaling and growth-promoting pathways.

Conclusions:

  • Inflammatory cytokines play a crucial role in the pathogenesis of growth disorders associated with chronic childhood diseases.
  • Understanding these cytokine-growth pathway interactions is vital for developing therapeutic strategies.
  • Further research is needed to elucidate the precise molecular mechanisms involved.

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