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Related Experiment Videos

Gametes and embryo epigenetic reprogramming affect developmental outcome: implication for assisted reproductive

Saji Jacob1, Kelle H Moley

  • 1Washington University School of Medicine, Department of Obstetrics & Gynecology, St. Louis, MO 63110, USA.

Pediatric Research
|September 9, 2005
PubMed
Summary

Assisted reproductive technologies (ART) may increase epigenetic disorders in infants. Further research is needed to confirm this link and guide cautious monitoring of ART outcomes.

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Area of Science:

  • Reproductive Medicine
  • Developmental Biology
  • Genetics

Background:

  • Assisted reproductive technologies (ART) raise health concerns for conceived children, including low birth weight and chromosomal anomalies.
  • Emerging evidence suggests a potential association between ART and increased epigenetic disorders in infants.
  • Epigenetic reprogramming, crucial for early development, involves DNA methylation, imprinting, and chromatin modifications.

Purpose of the Study:

  • To review the potential link between assisted reproductive technologies (ART) and epigenetic disorders in infants.
  • To highlight the critical role of epigenetic regulation in early development and the potential consequences of its disruption.

Main Methods:

  • Review of recent reports and existing evidence on ART outcomes and epigenetic disorders.

Related Experiment Videos

  • Analysis of the mechanisms of epigenetic reprogramming and potential disturbances during ART procedures.
  • Examination of specific imprinting disorders reported in ART-conceived children.

    • Main Results:

    • ART may be associated with an increased incidence of epigenetic disorders, including imprinting disorders like Beckwith-Wiedemann syndrome, Angelman syndrome, and retinoblastoma.
    • Potential causes include epigenetic alterations during embryo culture or altered embryonic developmental timing.
    • Disturbances in epigenetic reprogramming can lead to developmental problems and early mortality.

    Conclusions:

    • Further research is urgently required to establish a causal relationship between ART and epigenetic disorders.
    • Cautious national-level review of both short-term and long-term ART outcomes is recommended pending further evidence.