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Updated: Aug 16, 2026

A Rat Model of Compound Acne
Published on: November 1, 2024
Granular parakeratotic acanthoma
Kenneth S Resnik1, Gary R Kantor, Mario DiLeonardo
1Institute for Dermatopathology in Conshohocken, Pennsylvania 19428, USA. kresnik@ameripath.com
Abstract:
Granular parakeratosis was originally described as a dermatosis confined to the axillae that histopathologically shows characteristic findings in the cornified layer consisting of parakeratotic corneocytes housing keratohyaline granules. Since the original description of this entity, non-intertriginous examples and even incidental foci of granular parakeratotic corneocytes in association with other dermatoses have been recognized. This report details the findings of a previously unreported entity that we are naming granular parakeratotic acanthoma, which is fundamentally akin to acantholytic dyskeratotic acanthoma and epidermolytic acanthoma (ie, a solitary keratosis that histopathologically displays features indicated in its name).
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