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Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
09:11

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

Published on: February 23, 2016

Indications for cerebral revascularization for patients with atherosclerotic carotid occlusion

Colin P Derdeyn1, Robert L Grubb, William J Powers

  • 1Mallinckrodt Institute of Radiology and Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. derdeync@wustl.edu

Skull Base : Official Journal of North American Skull Base Society ... [Et Al.]
|September 9, 2005
PubMed

Insights

Patients with complete carotid artery occlusion and recent stroke symptoms face high risks. This article reviews treatments like bypass and angioplasty, focusing on hemodynamic factors for stroke prevention.

Area of Science:

  • Neurology
  • Vascular Surgery
  • Interventional Cardiology

Background:

  • Complete carotid artery occlusion with recent ischemic symptoms indicates a high risk of recurrent stroke.
  • Severe hemodynamic impairment due to inadequate collateral circulation exacerbates stroke risk in these patients.

Purpose of the Study:

  • To review the evidence for surgical and interventional treatments in patients with complete carotid occlusion.
  • To discuss the role of physiologic imaging in identifying high-risk patients based on hemodynamic factors.

Main Methods:

  • Literature review of studies on extracranial to intracranial arterial bypass.
  • Analysis of evidence for endarterectomy, angioplasty, and stenting of various arteries to improve collateral flow.
  • Discussion of the application of physiologic imaging techniques.

Main Results:

  • Evidence for specific interventions in complete carotid occlusion is evaluated.
  • The importance of hemodynamic assessment for patient stratification is highlighted.

Conclusions:

  • Treatment decisions for complete carotid occlusion should consider hemodynamic status.
  • Physiologic imaging can aid in selecting patients who may benefit from interventions to improve collateral flow and reduce stroke risk.

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