Related Experiment Video
Updated: Aug 16, 2026
Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
[Study on amplification of ZNF217 in primary gastric carcinoma]
Ya-qing Zhu1, Zheng-gang Zhu, Bing-ya Liu
1Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China. doctorzhuyq@sina.com
Objective:
To investigate amplification of zinc finger protein 217(ZNF217) and its association with clinicopathologic parameters in primary gastric carcinoma.
Methods:
Semiquantitative polymerase chain reaction (PCR) was used to determine DNA copies of ZNF217 in the specimens from forty- seven cases with primary gastric carcinoma.
Results:
There was no difference in DNA copies between tumor specimens and paratumor normal tissues. The incidence of ZNF217 amplification was 11.36% in gastric cancer. The amplification of ZNF217 was significantly associated with tumor size(P< 0.01) and intestinal type of stomach cancer(P< 0.05).
Conclusion:
Oncogene ZNF217 may play a role in specific tumor types or subtypes of gastric cancer. There may be other oncogenes associated with gastric carcinoma in 20(q)13.
