Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac allograft vasculopathy: a review.

Danny Ramzy1, Vivek Rao, Julie Brahm

  • 1Heart Transplant Program, Toronto General Hospital, University Health Network, Division of Cardiac Surgery, University of Toronto, Toronto, ON.

Canadian Journal of Surgery. Journal Canadien De Chirurgie
|September 10, 2005
PubMed
Summary

Cardiac allograft vasculopathy (CAV) is a serious complication after heart transplants. Preventing CAV by managing risk factors is crucial due to limited treatment options and poor outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum to 2025 American Association for Thoracic Surgery (AATS) Expert Consensus Document: Surgical management of acute myocardial infarction and associated complications: The Journal of Thoracic and Cardiovascular Surgery, Volume 170, Issue 5, 2025, Pages 1327-1344.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Fate of dilated ascending aorta after transcatheter aortic valve replacement.

JTCVS structural and endovascular·2026
Same author

IGF-1 levels, genetic polymorphisms, and intrameniscal platelet-rich plasma are associated with clinical response in a caucasian cohort with mild-to-moderate knee osteoarthritis.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2026
Same author

Single-Port Robotic-Assisted Epicardial Lead Placement for Cardiac Resynchronization Therapy.

Annals of thoracic surgery short reports·2026
Same author

No differences between medial opening and lateral closing wedge high tibial osteotomies to correct coronal alignment or cumulative rates of conversion to knee arthroplasty: A systematic review with meta-analysis.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2026
Same author

Accuracy, patient-reported and surgical-related outcomes in patient-specific 3D-printed versus standard high tibial osteotomy: A systematic review with meta-analysis.

The Knee·2026

Area of Science:

  • Cardiology
  • Transplantation Immunology

Background:

  • Cardiac allograft vasculopathy (CAV) significantly limits long-term survival post-cardiac transplantation.
  • CAV is an accelerated form of coronary artery disease (CAD) involving intimal hyperplasia in coronary vessels.
  • Both immunologic and non-immunologic factors contribute to endothelial dysfunction, injury, and intimal thickening in CAV.

Purpose of the Study:

  • To review the occurrence, pathophysiology, diagnosis, and treatment of CAV.
  • To highlight current research areas for CAV prevention and management.
  • To emphasize the importance of mitigating risk factors for improved transplant outcomes.

Main Methods:

  • Review of existing literature on cardiac allograft vasculopathy.
  • Analysis of diagnostic challenges, including limitations of angiography and intravascular ultrasonography.

Related Experiment Videos

  • Discussion of therapeutic strategies and preventative measures.

    • Main Results:

    • CAV diagnosis is challenging due to limitations in current imaging modalities.
    • Effective treatments for established CAV are limited, often necessitating re-transplantation.
    • Prevention strategies targeting endothelial injury are critical.

    Conclusions:

    • Mitigating immunologic and non-immunologic risk factors is paramount for CAV prevention.
    • Therapeutic interventions before, during, and after transplantation may protect against endothelial injury.
    • Further research into CAV pathophysiology and prevention is essential for improving cardiac allograft survival.