Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nephroscreen: a diagnostic test for predicting acute renal failure?

Marion A Howard1

  • 1Cambridge Biostrategies, LLC, PO Box 400971, Cambridge MA 02140, USA. mah@cambridgebiostrategies.com

Expert Review of Molecular Diagnostics
|September 10, 2005
PubMed
Summary

A new urine test, Nephroscreen, detects acute kidney injury days before traditional markers like serum creatinine rise. This early detection of acute renal failure may improve patient outcomes through earlier treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

The association between normalized creatinine-to-cystatin C ratio and incident Circadian Syndrome in middle-aged and older adults: a national cohort study.

Expert review of molecular diagnostics·2026
Same journal

What's in a name: the potential impact of the updated terminology of polyendocrine metabolic ovarian syndrome (PMOS).

Expert review of molecular diagnostics·2026
Same journal

Genomic profiling as an option for ovarian cancer diagnostics.

Expert review of molecular diagnostics·2026
Same journal

Falling short? Mitigating equity gaps and demographic bias in AI-driven molecular diagnostics.

Expert review of molecular diagnostics·2026
Same journal

Bacterial respiratory infections: advances in diagnostic strategies.

Expert review of molecular diagnostics·2026
Same journal

Artificial intelligence in molecular diagnostics for pandemic preparedness.

Expert review of molecular diagnostics·2026

Area of Science:

  • Nephrology
  • Biomarker Discovery
  • Clinical Diagnostics

Background:

  • Acute renal failure (ARF) is a common, often fatal complication in hospitalized patients.
  • Current diagnostic methods, relying on serum creatinine and glomerular filtration rate, indicate lost kidney function but not evolving kidney injury.
  • Pathological changes precede ARF, but current diagnostics lack early warning capabilities.

Purpose of the Study:

  • To introduce Nephroscreen, a novel urine assay for early detection of acute kidney damage.
  • To evaluate Nephroscreen's ability to identify pathological events preceding renal proximal tubule cell death.
  • To explore the potential of Nephroscreen in redefining and enabling earlier treatment of ARF.

Main Methods:

  • Development of Nephroscreen, a rapid urine enzyme-linked immunosorbent assay (ELISA).

Related Experiment Videos

  • Quantification of specific pathological events indicative of renal proximal tubule cell injury.
  • Comparison of Nephroscreen's detection timeline against traditional serum creatinine levels.

    • Main Results:

    • Nephroscreen quantifies pathological events preceding renal proximal tubule cell death.
    • The assay detects acute kidney damage days before elevations in serum creatinine are observed.
    • Nephroscreen offers a faster and easier diagnostic approach compared to current methods.

    Conclusions:

    • Nephroscreen provides an early warning sign for acute kidney damage.
    • This novel diagnostic tool may facilitate earlier intervention and more effective treatment of acute renal failure.
    • Nephroscreen has the potential to significantly impact the management of hospitalized patients at risk for ARF.